My 83 years old father is on Methotrexate(10 mg/week) for Temporal arteritis.He is also taking Prednisone 64 mg/day for the last month.His ESR is back to normal for the last 2 weeks.His general well being state is visibly worse in the second day of Methotrexate with difficulty breathing and violent cough lasting for 10 min and weakness.He also has difficulty chewing due to sore mouth and throat.Yesterday he also had diarrhea.