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How safe is it to get drunk after taking cialis? and will the cialis still be effective?

Responses (2)

Anonymous 10 Sep 2011

Hello,

Interactions between your selected drugs

ethanol ↔ tadalafil
Applies to: Alcohol (contained in alcoholic beverages) (ethanol), Cialis (tadalafil)
GENERALLY AVOID: Alcohol may potentiate the hypotensive effects of phosphodiesterase-5 (PDE5) inhibitors, and vice versa, as both are mild systemic vasodilators. In clinical pharmacology studies using tadalafil, more subjects administered alcohol at a dose of 0.7 g/kg (consumed within 10 minutes; equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male) in combination with tadalafil 10 or 20 mg single doses had clinically significant decreases in blood pressure than with alcohol alone. There were reports of postural dizziness, and orthostatic hypotension was observed in some. When tadalafil 20 mg was administered with alcohol at a lower dose of 0.6 g/kg (equivalent to approximately 4 ounces of 80-proof vodka), orthostatic hypotension was not observed, dizziness occurred with similar frequency relative to alcohol alone, and the hypotensive effects of alcohol were not potentiated. Neither tadalafil nor alcohol affected the plasma concentrations of the other. Sildenafil 50 mg and vardenafil 20 mg reportedly did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08% and in healthy volunteers administered alcohol at a dose of 0.5 g/kg, respectively.

MANAGEMENT: Based on known pharmacology of the drugs, patients taking PDE5 inhibitors should probably avoid consuming large amounts of alcohol, which may increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache.

Other drugs that your selected drugs interact with

Alcohol (contained in alcoholic beverages) (ethanol) interacts with more than 300 other drugs.
Cialis (tadalafil) interacts with more than 100 other drugs.

Interactions between your selected drugs and food

tadalafil ↔ food
Applies to: Cialis (tadalafil)
MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. However, the interaction seems to affect primarily those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability), presumably due to the fact that grapefruit juice inhibits intestinal rather than hepatic CYP450 3A4. Because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.

MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4. Grapefruit and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.

https://www.drugs.com/interactions-check.php?drug_list=1034-14582,2144-1395

Take care,

primetimegrape 10 Sep 2011

This is what I found off a good website, so be careful

ask your doctor about the safe use of alcoholic beverages while you are taking tadalafil (Cialis). Alcohol can make the side effects from tadalafil worse. Your doctor will tell you how much alcohol you may drink while you are taking this medication.

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