I have a long history of taking various meds - usually SSRI's. My normal pattern is they work great for some periois of time- weeks or months. Then one day they just stop working - nothing. Sometimes upping the dosage works for a while, but it always happens again. I've tried Lexapro, Celexa, Prozac, Paxil, Zoloft, Wellbutrin, Nortriptyline, Mirtazapine, Risperidone, and a few others I can't think of now. It's always the same. Previously I had just been seeing GP's but now I'm seeing a psych. He's trying me back on Celexa (since he knows it worked before), but at a higher dose than my GP prescribed (60 instead of 40mg/day). I've been on if for a month now and I haven't felt a thing. Have you heard of this type of this before? I know there are a lot of other meds out there to try, but it's so frustrating to repeat this pattern over and over. My psych also has me on Adderall ()up to 30mg/day if needed), and 2mg of Clonazepam. I also take Oxycodone for chronic lower back pain. Does anyone have any advice for me? I'm so frustrated I feel like there's something wrong with me - I just don't get why the meds don't work. I know this recent stint with Celexa has only been 4 weeks, so maybe I need to be more patient. But it was always months with all the other meds - success, sudden failure, up the dosage, temporary success, sudden failure, repeat until give up and try something else. If anyone has any advice please help. I'm so tired of this never-ending cycle. There must be something out there that can work for me. Thanks in advance for any comments or suggestions back.
Hello darthzilla. I have major depression and its refractory. So, as yourself, meds work, (if they do) be it usually a short period of time. Exception being the benzodiazipine sleeping meds. (Dalmane, Restoril) I might suggest a maoi, Monoamine Oxidase Inhibitor. They are as you propbably know, extremely powerfull antidepressants that are used when traditional antidepressants fail. A diet is needed, for you're to avoid certain foods and so on.( absolutely no tyramine) I was on Tranylcypromine (Parnate) and it worked for awhile. Felt very well. Unfortunately, it also stopped working. But, for so many, it does get the job done. People do well on the Maois. And put up with the side effects and diet. Its worth a shot, because at this stage, you're frustrated with the tradtional anti-depressants, so why not? Give it a go, and if you find its not for you, then you'll have known that this option was used.very best to you,
I recommend the SNRI's as you have tried the SSRI's and the tricyclics. You might also ask the doctor to check your blood folic acid levels as a low folic acid level will affect the antidepressant effects. Also, might suggest a med such as Abilify which helps enhance the effects of the antidepressant. Just some thoughts to investigate.
My combo of meds aren't all that far from yours. I'm currently on 150mg Efexor, 2mg Klonopin, 35mg Methadone (for fibromyalgia), 300mg Tramadol (yup, back on the stuff for the fibro) and 60mg Ritalin (so I don't fall asleep all the time due to all of the depressant type drugs). Due to therapy, my antidepressant usage has been getting less and less, but in the beginning I was taking a substantially larger dosages, trying out a ton of different meds before finding one that worked for me. I started with Zoloft, then Lexapro, then Celexa, then Celexa with Wellbutrin, then Pristiq. Pristiq was the bingo for me. The others all worked, but I couldn't stand the side effects, made me feel way too tiered. Unfortunately, after a year the Pristiq stopped working... so we upped it from 50mg to 100mg's per day. That didn't seem to do much of anything, so we went onto Cymbalta which worked out just fine for me.
When I lost my job and insurance, I switched over to Efexor due to cost.
I'm surprised that the only medications that you've tried are all SSRI's. I would think that giving an SNRI a try wouldn't be such a bad thing. You may need something that hits on a few more receptors than just the serotonin. On the off chance that your body is having a hard time producing serotonin, the other actions of the SNRI class of meds might be of some help.
I am of course not a doctor, but am just giving you a guess. There's also the TCA's a class of drugs that are just as effective as are the SSRI's, the only real difference is that you can OD if you gulp down a full bottle. You may also need to get an ekg to ensure that your heart won't interact with them in a negative manner (if your heart turns out to be all good, you really have nothing to worry about). It just seems odd to me that after trying so many SSRI type drugs, that none of the other types have been considered.
Hope that this is of some help to you,
There is something else to try - Transcranial Magnetic Stimulation (TMS). It was FDA approved in 2008 for treatment of depression in patients that medications failed to help. It doesn't invoke meds at all - just 20-30 sessions of about one hour over 6 weeks (5 a week) lying back in like a dental chair with some equipment containing magnets and electricity up against your head. No pain, nothing harmful. Success rate is over 70% have no more depression! None! Insurance is starting to cover it - google TMS and read about it. Some people have found help with ECT and Vagus Nerve Stimulation also. It's tough to accept living with being depressed - for me I had to keep on trying and TMS helped me a lot. -
You don't give up at all. I had a psychotic episode when I was prescribed Seroquel and was admitted to the hospital for major depression. It took 6 months before they found the right meds for me. If I would of gave up I would not be home with my family and happy again. I have my life back and am normal again. Thank God!
in march i was diagnosed with major depression severe recurrent with impaired concentration first i started with wellbutrin 50 then eventually to 100mg twice a day. in august zoloft was added. but in september i had a seizure so the wellbutrin was stopped and i stuck with just zoloft but alone it was not working so i stopped in october and switched to effexor it may be almost a month can't really say how well it is working because im still saddd as ever and sometimes i just feel like when do you just quit im tired of switching from med to med like a guinea pig i just want it to work!!!
- Celexa Information for Consumers
- Celexa Information for Healthcare Professionals (includes dosage details)
- Side Effects of Celexa (detailed)
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