You have to be in moderate withdrawal from the lortab before the suboxone will sit on the receptor sites and work. At least 24 hours after your last dose of both drugs. If you are taking a high dose of either, over 10 lortab a day or over 4 xanax a day, you need to wait a bit longer than that. You can google the Clinical Opiate Withdrawal Scale ( COWS Sheet ) and you are looking for a score of at least 26 before you start. You can throw yourself into precipitated withdrawal if you take it too soon, this means megawithdrawal. You are not supposed to take Xanax ( or any other benzo or drink alcohol ) with suboxone. If you can stop the Xanax a few days before the lortab to make sure it is out of your system, that would be great.
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