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How long does it take for penicillin to leave your system?

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Marvell 25 Apr 2010

Elimination
Renal (largely unchanged); hepatic inactivation and excretion in bile; t ½ 1.4 h or less.

It takes approximately 5.5 elimination half life's for a drug to be totally cleared from your system. Elimination half life of penicillin is 1.4 hours therefore after you last dose it will be out of your system in approximately 7.7 hours (5.5 x 1.4 hours).

https://www.drugs.com/ppa/penicillin-g.html

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