You can take a short acting opiate like Oxycodone, Hydrocodone, or even Morphine in 12 hours. I have had to do that more than once since I've been on Sub. You will need a larger than usual dose, and it will wear off faster. You will also not feel a buzz. However, I'm not sure about Methadone. I don't think taking Sub and Methadone close together is a good idea. But I suppose it has been done. If you then need to go back to Sub from Oxy, I suggest you wait until you feel wds, and even then, go back slowly, like 1 mg at a time until you're sure you won't have precipitated wds. This is how I did it and I was fine.
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