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How is tamoxifin absorbed in body?

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Marvell 30 Jun 2011

I realize this answer is a bit late but may help someone later. ... and I hope this is the answer you were looking for.

Absorption and Distribution

Following a single oral dose of 20 mg Tamoxifen, an average peak plasma concentration of 40 ng/mL (range 35 to 45 ng/mL) occurred approximately 5 hours after dosing. The decline in plasma concentrations of Tamoxifen is biphasic with a terminal elimination half-life of about 5 to 7 days. The average peak plasma concentration of N-desmethyl Tamoxifen is 15 ng/mL (range 10 to 20 ng/mL). Chronic administration of 10 mg Tamoxifen given twice daily for 3 months to patients results in average steady-state plasma concentrations of 120 ng/mL (range 67 to 183 ng/mL) for Tamoxifen and 336 ng/mL (range 148 to 654 ng/mL) for N-desmethyl Tamoxifen. The average steady-state plasma concentrations of Tamoxifen and N-desmethyl Tamoxifen after administration of 20 mg Tamoxifen once daily for 3 months are 122 ng/mL (range 71 to 183 ng/mL) and 353 ng/mL (range 152 to 706 ng/mL), respectively. After initiation of therapy, steady-state concentrations for Tamoxifen are achieved in about 4 weeks and steady-state concentrations for N-desmethyl Tamoxifen are achieved in about 8 weeks, suggesting a half-life of approximately 14 days for this metabolite. In a steady-state, crossover study of 10 mg Tamoxifen citrate tablets given twice a day vs. a 20 mg Tamoxifen citrate tablet given once daily, the 20 mg Tamoxifen citrate tablet was bioequivalent to the 10 mg Tamoxifen citrate tablets.

https://www.drugs.com/pro/tamoxifen.html

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