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How is tamoxifen absorbed distributed excreted and metabolized?

Responses (1)

teknotard 24 Mar 2011

I took this from Micromedex:

Absorption
Oral: time to peak concentration, approximately 5 h
Oral tablet, pediatric: time to peak concentration, approximately 8 h
Metabolism
Hepatic: extensively; substrate of CYP3A, CYP2C9 and CYP2D6; Active metabolite: N-desmethyl tamoxifen
Excretion
Biliary/fecal: 65%, less than 30% unchanged; Renal: only small amounts
Elimination Half Life
about 5 days to 7 days
N-desmethyl tamoxifen (active metabolite): approximately 14 days

Brian PharmD Candidate

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