My mother is in end stages of cancer and hospice just became involved. She has been on 100 mg Methadone for a few weeks with Hydrocodone 10/325 for frequent breakthrough pain., which has been working well. Hospice wants to switch her to 60 mg MS Contin daily, with the hydrocodone still for breakthrough pain PRN. She has been on Methadone for about two years for fibromyalgia, but on low doses. Doses only began increasing a few months ago due to the cancer pain. Will the new regimen control her pain and will she experience any withdrawal symptoms? The only promise I could make to her when this started was that we would control her pain, and I hope to keep it.