I have been experiencing my fair share of both pain and anxiety. I don't know why I can handle 25mg of Opana ER sometime, and other times, my body goes into a very painful set of symptoms that is clearly detox. Why can I handle this dosage at times, and not other times. I know I have to depend on GOD to bring me to the place I am okay on this dosage. I am so tired of day in and day out facing my taper! I need hope! How do you cope with withdrawal and anxiety? I am a little afraid of using xanax or clonazapam since I was really addicted to them before. Marie