How do Aplenzin and generic bupropion differ with regard to effectiveness? My Dr. gave me samples of Aplenzin. I have been taking 522 mg. daily for 6 weeks. I have been experiencing great improvement in my depression symptoms. Unfortunately, I just learned that my monthly insurance copay for Aplenzin is $465! As this is far beyond what I can afford, I asked my Dr. for a substitution. She prescribed 150 mg. of generic bupropion twice daily. What kind of difference(s) might I experience with the change?
I realize this answer is very late... but generic bupropion and Aplenzin shouldn't work any differently.
Aplenzin (bupropion) is an antidepressant medication.
Aplenzin is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder. It is supplied as an extended-release tablet.
There is a significant difference in my experience. I tried the other variations of Wellbutrin (not to mention the seemingly dozens of other antidepressants available), but couldn't tolerate them.
When Aplenzin came along, I was delighted with it. None of the side effects of the others, and the desired effect -- antidepressant -- was there. I've been on it for years, altho my doc says it may be time to get off it.
Apparently, the bromine element is what did the trick. (The chemical description is "buproprion hydrobromide") The other variations of buproprion I tried were based on chlorine. That is, "buproprion hydrochloride." The doc wasn't sure bromine would make any difference (various publications claim the two formulations are equivalent), but thought it was worth a try. I'm glad I tried it ... it made a world of difference for me.
Of course, if a generic works for you, that's the way to go from a cost standpoint. But if Aplenzin is the ONLY antidepressant that works and is tolerable, well ...
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