How do Aplenzin and generic bupropion differ with regard to effectiveness? My Dr. gave me samples of Aplenzin. I have been taking 522 mg. daily for 6 weeks. I have been experiencing great improvement in my depression symptoms. Unfortunately, I just learned that my monthly insurance copay for Aplenzin is $465! As this is far beyond what I can afford, I asked my Dr. for a substitution. She prescribed 150 mg. of generic bupropion twice daily. What kind of difference(s) might I experience with the change?