They can be taken together but with caution, as Sildenafil may potentiate the hypotensive effect of alpha blockers (tamsulosin), resulting in symptomatic hypotension in some patients.
Caution is advised if sildenafil is used in combination with alpha blockers. Patients who demonstrate hemodynamic instability on alpha blocker therapy alone are at increased risk of symptomatic hypotension with concomitant use of sildenafil. Therefore, patients should be stable on alpha blocker therapy prior to initiating sildenafil, and sildenafil should be initiated at the lowest recommended dosage when used for erectile dysfunction (i.e., 25 mg).
Please see link below for interaction in detail.
- Tamsulosin Information for Consumers
- Tamsulosin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Tamsulosin (detailed)
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