I have heard alot about the Seretonin Syndrome and I know that both Celexa and Luvox are SSRI's but a psych. just put me on celexa and well i have been on luvox forever but i don't trust doc's much these days so although he didn't seem to have a prob. with me being on both I wanted to see what everyone here knows about being on both
Hi everyone! Can anyone tell me if you can take Luvox and Celexa at the same time?
- 27 Jun 2011 by JennyLynn4eva
- 27 June 2011
- celexa, luvox, depression, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, anxiety and stress
Interactions between your selected drugs
fluvoxamine ↔ citalopram
Applies to: Luvox (fluvoxamine), Celexa (citalopram)
MONITOR: CYP450 3A4 and CYP450 2C19 are the two primary enzymes responsible for the metabolism of citalopram and escitalopram. Concomitant use with a drug that inhibits both the CYP450 3A4 and CYP450 2C19 enzyme systems may decrease the clearance of citalopram or escitalopram and increase its serum concentration. In addition, combination with other selective serotonin reuptake inhibitors (SSRIs) may potentiate the risk of serotonin syndrome due to hyperstimulation of brainstem 5HT1A receptors.
MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever an enzyme inhibitor is added to or withdrawn from therapy. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
Other drugs that your selected drugs interact with
Celexa (citalopram) interacts with more than 300 other drugs.
Luvox (fluvoxamine) interacts with more than 500 other drugs.
Interactions between your selected drugs and food
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
As maso pointed out, taking celexa with luvox is not recommended. I would be reluctant to take two SSRI's at the same time. In this case the luvox can inhibit the enzymes that help metabolize the celexa causing the celexa to increase in the blood and there is the risk of serotonin syndrome as you mentioned. Is it the intention of the doctor to eventaully discontinue the luvox? He may have you at a low dose of celexa to see how you respond and then plans on discontinuing the luvox while eventually increasing the celexa. If this is his plan then you are ok to take them both, if in fact the celexa is at a low dose. I can see no other reason for being on the two SSRI's. Maybe it would be best to get clarification from the doctor by specifically asking about serotonin syndrome and whether he intends on eventually discontinuing the luvox.
Just my thoughts,
I really do agree, with all of these warnings, Please listen to your own voice. It has told you just as these wise people have advised you. They understand the chemicals involved. But my advise, is to understand that doctors are people that make educated guesses, and often are under extra pressure from the insurance companies. And I personally do know that they do indeed make mistakes, that can cause more harm than the problem. Please do not use all of these drugs all together they will hurt you. I have had the most help from therapist. Good luck
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