twice a day to loose weight. Well it did not go well. It made me tired alot. It constipated me and I felt nauseated alot and vomited twice in one week. I'm not diabedic so it I felt like I was hypoglycemic. My endocronologist said she did not see this med as a good optiion to loose weight. I did not loose weight at all. I fell so much better now that I'm off them. Thanks for the support. I appreciate it. Smileyhappy.