After 4 weeks my VL was under 15 but I was still positive for hep c. At 8 weeks, I was negative. I read your other posts and was wondering what your genotype is as well as whether you have cirrhosis. I am 1a, the best genotype for harvoni and I don't think I have cirrhosis. The doctor did not want to take the chance of a third biopsy even though the last one was 15 years ago. He only gave me 12 weeks on harvoni so insurance would cover it. They did immediately. I am very curious to find out if the "cure" will stick or if relapse is possible. I assume you don't drink. I'm sorry you have been put on ribaviron also. I did take interferon alone and with ribaviron in two separate tries before 2001. Your life seems so stressful now. I wish you could back away from all or any of these other things you do. I made absolutely sure before treatment on harvoni that I would not need to do anything.
I'm 64, don't work but I even paid my bills ahead, and had to tell a friend who just lost her car I can't even give her a ride to get doctor. The harvoni makes me too sleepy to drive safely in the morning. My preexisting insomnia makes it impossible to sleep before 4 am. Try to put yourself first. Do you have new test results yet. Even people in stage 3 report they are undetectable. There are some drugs I think that might show incorrect results in your blood tests. This website should show it though if you enter all your drugs and OTE meds.
I started Harvoni treatment Dec., 4, 2014, I finished treatment on Feb 28th, 2015, I have had Hep C since 1991, through blood transfusion, I have not smoked or drink alcohol for 23 years, I am early stage 2, genotype 1, no cirrhosis, my VL was 13 mil, at 2 wks on Harvoni my VL was 800, at 4wks 0, then at 6 wks back to 15, 8 wks still minutely traceable, 10-12 wks untraceable, I had my 90 follow-up on Thursday May 5th, 2015 and my VL is at 16mil, the virus is back, the 12 week Harvoni treatment did not work for me, I am 1 of 16 patients I know of this did not work for, I have appt on June 4, 2015 for other treatment options, my Infectious Disease Dr did say I have a 20 % chance of dying from liver failure in my 90 's living the lifestyle I live today which is exercise daily, no smoking, or alcohol. I just want the virus out of my body so I am looking at other options.
I am 60, have probably had Hep C, genotype 1, since I was 19 but was diagnosed in 2011. I had a VL of 6M with no cirrhosis, healthy lifestyle and no symptoms upon diagnosis. I began taking Harvoni on 11/24/14 and completed my 12 week course on 2/16/15. My 4, 8 and 12 week labs all showed a zero VL. I had a 12 week followup with my doctor to determine my final diagnosis, as standard protocol indicates. If my VL remained at zero I would be pronounced cured. However, my lab results showed a VL back to 6M so therefore have relapsed. I followed the required regimen and took Harvoni daily like clockwork continuing to lead a healthy lifestyle. If the cure rate is actually 96% then I'm in the 4 percentile group. My doctor took more blood today to check the genotype and VL again and I'm talking to him next week to look at possible options.
I completed Harvoni treatments several months ago. Zero virus detected after the first month, by month 5 it returned. No drinking, exercise and eat right. Strange enough, when I asked about relapse before I started this expensive treatment, I was told 90+% were cured. Guess I'm part of the 10% that relapsed. I beat cancer back in 1994 with odds lots worse than this... but this HCV - well... I'm depressed now - more than I ever was before I heard there was such a great treatment on the market.
Pretty sure I failed Harvoni. I have GT 1a and was treatment naïve back in late June when I was started on Harvoni. I was scheduled to be treated for 12 weeks as I have compensated cirrhosis. My first viral load was 398 down from 6.1 million. Second viral load at eight weeks was 50. I was started on ribavirin at that time as they thought I was a slow responder. After 10 days of taking ribavirin I had side effects that my doctor considered severe enough to stop ribavirin. I did not want to stop the ribavirin but apparently the visual changes were a clear indicator that I should not continue on ribavirin. At that time I was approved for an additional four weeks of Harvoni. Which would bring my total treatment time on the medication to 16 weeks. I am told that I am I the unfortunate 4-6 % that won't clear.I am still awaiting results from my 16 week viral load. I don't have a lot of hope that I will clear.
It's official I failed Harvoni. Just received my 4 week post treatment labs. I have read about others that failed, resistance testing is an option,unfortunately not all care centers are as progressive as others. You need to advocate for yourself and become as knowledgeable as you can. I say this from experience as a patient, mother of a terminally ill child and working in the health care field fo 30 years. When the majority of a disease specific population respond favorably to a treatment there is a tendency to assume that the nonresponders are at fault. Which is so wrong. I am actively seeking care else ware because of the lackadaisical attitude and care I have received.
I did peg-interferon and almost died from toxic seizure back in 97. Took me a long time to regain some sort of life. I kept hearing all the (BS) hype about treatments and I knew it was not for gyno type 1a. All cooked up percentages by big pharma. My Dr kept threatening me about if I was not going to take treatment, then I wasn't disabled. I still refused. I heard about Harvoni and was very skeptical, but with all the (BS) being fed to us by big pharma, I decided to give it a go. Went on 12 week treatment... major head aches, very fatigue, all i could do i sleep, eat and go to bathroom. When I would go outside to do anything, I would get bright red n face and hard to breath and extremely tired. I kept having weird feeling n my chest (heart area). Tested after 6 weeks and labs showed hep c neg. After 12wks labs again showed cleared. Just got labs back after treatment it has been 4 1/2 months off of Harvoni and hep c is back.
Not only is it back, but higher viral load then every. Not only that, but been in more pain and triglycerides hav spiked to 348. So, we have another hyped up med, costing people so much money for failed outcome... once again. But now that big pharma has stuffed their pockets, let's all giv it another round... right?
I just found out that I failed 24 weeks of Harvoni. With medicare it cost me $12,000.
I had been in a clinical trial 3 years ago for daclatasvir and asunaprevir and failed that also.
I never missed a dose, took no antacids and always dosed at 6am. I don't have any idea what to do now.
F3 viral load 3 million. After 12 weeks of harvoni viral load 8,000. So I'm a non responder. Also failed interferon and rebitol in 2002. 6 months of torture. Now there is zapatier. A trial (free) is going on but I am going to pass. The trial is zap and rebitol aka ribivarin. Some get ribivarin some dont. Blind study.
I have just come of a consultation with my doctor after having treatment with harvoni.
My VL was apparently clear after 2 days, the same at 4 weeks, 8 weeks & 12.
I have just been for what was to be my final appointment 12 weeks post last harvoni tablet & got the shock of my life, the doctor told me the virus was back. They didn't offer any new treatment path, just told me to come back in 6 months of that they can do a fibroscan to see if my liver is getting more damaged.
My question is to anyone who has been in this position, do you know of any other treatment options.
Thanks in advance, I am in the UK
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