... friday because iam off saturday and Sunday and figured it would be a good time to sit back and let it work and by Monday morning when i go back to work I will have an idea of how it effects me... so my question is why do most people take it in the morning instead of evening right before bedtime... seems like if you take it at night you could sleep through some of the side effects. Also using a heating pad has always helped me in the past with migraines just maneuver it where ever the pain is... I get instant relief... better than any headache meds out there and noooooo further damage to our livers either