... I just joined this group and just recently started taking .50cc of 50m/2ml Methotrexate weekly 3 weeks ago. I also take celebrex 400mg daily, zoloft 100 mg daily, celexa 40 mg daily, prednisone 10 mg daily, lyrica 100 mg three times daily, folic acid 10 mg daily, and metformin 100 mg daily, plus a few vitamins and supplements as well. (As if that is not enough!) My question is for those who inject Methotrexate. How long did it take for you to adjust to the medicine? My experience has been that on the second day after injecting, I feel the worse. Any similar reactions? Thanks in advance for answering