... been on Xyrem about two weeks. As of last Thursday ive had an almost constant headache. I started drinking Pedialyte thinking that rehydrating was a good idea, but then the pharmacist says that its the high salt content that may be contributing to the headaches. So pedialyte is not the way to go. She did say that most patients start to have fewer incidences of headache after about a month. I'm hoping hoping hoping. Anyone have any experience or knowledge about this? I'm hesitant to take NSAID's b/c I have digestive issues. Xyrem is one of my last hopes. I have fibromyalgia and have tried almost every other sleep med on the market