... specifically in bicuspid aortic valves?
Has research proven that simvastatin can slow the progress of calcification in aortic valve disease?
Added 8 Jul 2010:
I was diagnosed with severe aortic stenosis (0.8 c2 area) due to bicuspid aortic valve and was recommended to have aortic valve replacement. I don't have heart failure and my heart is not enlarged. I was looking into the possibility of not pursuing a heart surgery if the stenosis will not progress, or if simvastatin can reverse the calcium deposits in my aorta.
Simvastatin is a powerful lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. It is used in doses of 5 mg up to 80 mg. Higher doses (160 mg) have been found to be too toxic, while giving only minimal benefit in terms of lipid lowering. There is also evidence of raising high density lipoprotein (HDL) and lowering triglyceride (TG) levels.
From recent research it has become apparent that simvastatin and other statins inhibit the progression of atherosclerosis beyond their effects on LDL. Many explanations have been proposed, for example its inhibitory effect on macrophages in the atherosclerotic plaque lesions.
In one Non-randomized study, simvastatin halved the risk of developing dementia or Parkinson's disease.
Simvastatin: What Should I Tell My Healthcare Provider?
Simvastatin (Zocor®) is often used to treat high cholesterol and high triglycerides. You should consult with your healthcare provider prior to taking it if you have:
Liver disease or liver failure
Kidney disease or kidney failure
A family history of high cholesterol (hypercholesterolemia)
A history of a heart attack or stroke
best wishes ... from a caring individual
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