I am considering Topamax because I am starting to have migraines again and I want to make sure it will not make sick to take all of these together. It sounds like I may be able to stop the Klonopin since I only take 1 mg at night for sleep aide.
Interactions between your selected drugs
lithium ↔ clonazepam
Applies to: lithium, Klonopin (clonazepam)
MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.
MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
lithium ↔ topiramate
Applies to: lithium, Topamax (topiramate)
MONITOR: Coadministration with topiramate may increase the serum concentrations of lithium. The exact mechanism of interaction is unknown, but may involve reduced lithium elimination due to competition by topiramate for renal excretion and/or sodium depletion secondary to the inhibitory effect of topiramate on carbonic anhydrase. There have been isolated case reports of patients treated with lithium who developed symptoms of toxicity (e.g., impaired concentration, confusion, memory loss, lethargy, tremor, bradycardia, nystagmus) in association with elevated serum lithium levels following the addition or increase in dosage of topiramate. Temporary withdrawal of lithium and dosage reduction upon reinitiation were necessary to maintain therapeutic levels during coadministration with topiramate. In healthy volunteers, topiramate at a dosage of 200 mg/day has been found to exhibit little or no pharmacokinetic interaction with lithium. However, increases of 27% in peak concentration (Cmax) and 26% in systemic exposure (AUC) of lithium have been observed following topiramate dosages of up to 600 mg/day.
MANAGEMENT: Caution is advised if lithium must be used in combination with topiramate. Pharmacologic response and serum lithium levels should be monitored closely and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of topiramate in patients who are stabilized on their lithium regimen. Patients should be advised to notify their physician if they experience early symptoms of lithium toxicity such as drowsiness, dizziness, diarrhea, vomiting, muscle weakness, ataxia, tremor, blurred vision, tinnitus, excessive thirst, and increased urination.
No other interactions were found between your selected drugs.
Note: this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
Other drugs that your selected drugs interact with
lithium interacts with more than 500 other drugs.
Klonopin (clonazepam) interacts with more than 300 other drugs.
Topamax (topiramate) interacts with more than 200 other drugs.
Interactions between your selected drugs and food
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
All the best and take care.-
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