As a base seizure medicine I am taking 2000 mgs (4 pills) of Keppra in the a.m./p.m. My neurologist is slowly increasing every 5 days using Depakote ER, 500 mgs... 1 p.m. (days 1-5), days (6-10) 1 a.m./1 p.m. and then days 11-15 and beyond (1 a.m./2 p.m.)...