Ive gained 18 ponds in just 5 months on Gleevec and it's driving me mad!!! I had surgery for GIST last Oct (2010)... 95%was removed & Gleevec is working well on what was left behind but not without weight gain,muscle ache, major fatigue, & blood counts stabilized after 1st month being hospitalized with neutrpenia, but the weight gain is absolutely,as said , driving me mad! I eat within calorie range of 1200 to 1600 and exercise 3 - 4 times week walking & running easy.
Has anyone figured out a solution to the weight gain on gleevec? I am a physician and cml patient. I was dx'd last year and gained over 40 lbs since I started gleevec. I am 5'11" male and keep to a 1600 kcal diet and that barely keeps my weight stable now. The weight gain is genuine, it is not water weight. Losing weight has been impossible. Most research reports weight gain with gleevec use but no solution or cause.
Theories I've come across are as follows:
1. Metabolism decreases after successful treatment
2. In male mice, Gleevec decreases testosterone... humans too?
3. Gleevec causes decreased thyroid function
- Gleevec Information for Consumers
- Gleevec Information for Healthcare Professionals (includes dosage details)
- Side Effects of Gleevec (detailed)
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