After many years and many UTI's my doctor has put me on bactrim for 90 days. I am finding that my hands seem swollen and I have had some anxiety that I didn't relate to bactrim until I saw it mentioned in other questions. I am on a low dose of dieuretic for mild/pre blood pressure problems and find that I am urineating less often and frequently feel very sleepy, except at night when I can't seem to fall asleep.