A year and a half after starting Humira and methotrexate, my daughter (age 24) experienced extreme anxiety, weird and intrusive thoughts, fear that she was dying or fear that she would harm herself or others, and a 25 pound weight loss over a few months time. She's never had anything like this before. She's better now, but it was so atypical, I've always wondered if it might have been from her RA meds. She still deals with more than the usual amount of anxiety, emotionality and negativity. Her RA responded beautifully to the meds., so she has stayed on them.