I have been on Zoloft for 6 years (depression), methadone for 9 years (to combat a drug addiction issue. I have been slowly decreasing my dosage (35mgs), Lyrica for fibromyalgia (150mg twice a day-this does absolutely nothing for my pain, BTW), Klonopin for occasional anxiety (I rarely took this until I started taking the Cymbalta). I don't know if the Cymbalta is making me anxious, nervous, or just crazy. At first I thought it may be withdrawal symptoms from decreasing the methadone, but I have been decreasing my dose super slowly. The last time I decreased it was nearly 2 weeks ago, and right now I feel like I am so wound up. I have cold sweats, I'm irritable, angry, and just really bitchy. I feel as if my pulse is racing and I can't catch my breath. I'm thinking it is the Cymbalta reacting to one of my other drugs. Help?