I took allopurinol for 1 month endd up in Akron Childrens Hospital Burn Unit with 2nd degree burns over 65% of my body. Had surgery to remove the sluffing skin and eye surgery. I was in thehospital for 5 weeks. Was not expected to make it through the sickness. It was TENS. I now have lung and eye problems.
I also had a bad reaction. It began with flu-like symptoms followed by severe arthritis. My PCP noticed a high ESR (sed rate) and treated me for rheumatoid arthritis. High doses of NSAIDS wreaked havoc on my GI tract and provided limited relief. After receiving advice on the Arthritis News Group mail list, I asked for a referal to a rheumatologist. He diagnosed it as either Wegener's granulomatosis or polyarteritis nodosa based on one of the ANCA titers and a positive renal ultrasound and treated me with prednisone. I had independently stopped taking allopurinol and about 6 weeks later, my symptoms disappeared. I was not suspicious due to the long time lag but mentioned it to the rheumatologist who didn't think it was a factor. Going back on allopurinol to forestall a return of gout symptoms resulted in a prompt return of symptoms... again we considered it a probable coincidence but terminated allopurinol and started prednisone therapy again. Symptoms resolved again and after some time, he suggested that I didn't want gout again and to resume allopurinol. That resulted in an immediate spike in antibody titer and a month or so later, a return of arthritis symptoms. We immediately stopped the allopurinol and after a short course of prednisone, I was free of symptoms again. It has been 15 years now since the last flare-up. I take 500 mg of probenecid daily to prevent gout and have had no attacks during the years. I have some residual loss of renal function that shows up in routine lab work and some residual neuropathy in one foot, a slight numbness. 3 tests with allopurinol and 3 episodes of severe symptoms... pretty conclusive in my book.
- Allopurinol Information for Consumers
- Allopurinol Information for Healthcare Professionals (includes dosage details)
- Side Effects of Allopurinol (detailed)
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