I have been taking the Savella titration pack. When I upped from 12.5 to 25 twice a day I started experiencing bad side effects. The first thing I noticed was a sickeningly sweet vanilla smell to my skin. Then I had heart palpitations and it felt like someone is sitting on my chest. Finally, I had migraines, with horrendous sweating. My doctor adjusted my dose down to 12.5 twice a day and I intend to stick with this medication. I have suffered for over 10 years and have tried every medication under the sun. Any improvement is worth the trouble. For those of you who feel the desire to be normal again, I will tell you what my Doctor told me, " Normal is a setting on the Dryer and should not be what we strive for." Increased functionality is my goal!