In addition to headache, nervous stomach and general restlessness, I became increasingly depressed from the 2nd day onward, and had to stop the medication on the 5th day, with my Dr.'s okay. After about 24hrs of being off the med, my symptoms have been only slightly relieved. I am really suffering with physical and mental symptoms and would like to know how long I have to wait to feel better. (I suspect buproprion interaction to be the cause.)