I have taken Cymbalta 60mg once a day for over 5 years now. Up until about 6 months ago, Cymbalta was ideal for me after spending years testing out different anti-depressents. I have major depression and severe anxiety. I'm wondering if anyone has had a similar medication change (specifically Cymbalta to Prestiq) and, if so, what was the difference between the two and were there any side effects. With Cymbalta, I did gain a little weight, lose sexual sensitivity (especially the ability to orgasm), and feel extremely tired.