I have had Hep C genotype 1 for 40 yrs,took interferon/ Ribavarin combo 16yrs ago, for 11 months, no cure, horrible experience, In comparison HARVONI is. Cinch! But I did have some bad headaches first 3 weeks but when I increased my water intake from 8 to 12 cups they were gone, fatigue is bad for me Bout 2 hours after I take HARVONI with my dinner and then again in the morning but it's gets better in a few hours. I've been sleeping well too. The only other meds I take is for HIgh blood pressure which is usually 130/70. All in all its been pretty good considering what I experienced in the past. BTW no alcohol for me until the treatment is completed and then a glass of champagne to celebrate!