Any suggestions? I have tried varying the time I take my 800 mg of Votrient. Best time for me seems to be around 3:00 PM so I can try to eat my supper around 5:00 or 6:00. I take Zofran about 2 hours after i take Votrient but its effects are short lived. My doctor has tried me on Reglan but i started to get shaky after about a week and I couldn't get to sleep at night. I keep waking up around 2:00 or 3:00 am nauseated and throwing up. My doctor does not want to reduce me to 600 mg dose.