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How does Genvoya dosing compare to Stribild?

Answers (1)

Official Answer by Drugs.com 9 Mar 2016

Genvoya (generic name: cobicistat, elvitegravir, emtricitabine, and tenofovir alafenamide) and Stribild (generic name: cobicistat, elvitegravir, emtricitabine, and tenofovir disoproxil fumarate) are antiviral combination medications and both are used to treat HIV-1 infection.

However, Genvoya is approved for use in patients who are 12 years and older, and Stribild is only approved for adults 18 years and older.

The dose for both Genvoya and Stribild is one tablet taken orally once daily with food.

Neither drug is approved for use in patients co-infected with both HIV and hepatitis B virus (HBV).

There are some differences in how these drugs are dosed in patients with renal (kidney) impairment. Genvoya is not recommended in patients with estimated creatinine clearance (CrCl) below 30 mL per minute because data in this population is insufficient.

Initiation of Stribild is not recommended for patients with estimated CrCl below 70 mL per minute. For patients already taking Stribild, the drug should be discontinued if estimated CrCl declines below 50 mL per minute during treatment.

In patients with hepatic (liver) impairment, neither drug is recommended for use in patients with severe hepatic impairment (Child-Pugh Class C).

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