I've been taking liothyronine 22.5 mcg for 4 months and have been steadily gaining weight. My doctor said she didn't understand why I was gaining weight because even if my appetite was increased, I should have been burning everything off. I had a thyroid blood panel done and it was discovered that my TSH(I think) was .01. She said that it was high and took me down to 15mcg. It seems I am still gaining weight. I am anxious to find a reason for this. PLEASE anyone who has any insights, let me know!