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I take gabapentin 600 mg 3 times a day dr wants to change this to lyrica So what should be new dos?

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yearsofit 6 Apr 2016

As you probably know, there are at least three similar meds: gabapentin also called Neurontin, pregablin also called Lyrica, and newer gabapentin enacarbil also called Horizant. Lyrica is usually a much lower mg dosage. Most dosage prescribing is probably based on FDA recommendations, so it might help to go to fdadotgov and search for Lyrica and look at the brief Highlights of Prescribing Information pdf. It will probably show a maximum of 600 mg per day or 450 mg per day depending on condition and also renal function, so mg are definitely different between the two meds. There is also a longer Lyrica Medication Guide pdf that gives brief info about using Lyrica and Gabapentin together, but admits there are limited studies. FYI, Horizant is a somewhat extended release of gabapentin that might give better absorption, but was only approved for restless leg and postherpetic neuralgia as of 2012 due to some cancer concerns.

Per your question, one might look at your current 1800 mg/d of gabapentin, which from what I know is half of the normal maximum, and think you might be placed at half the maximum of Lyrica. However, your doc may have some adjustments in mind while switching. Only a guess, but switching to a more expensive med is usually because something isn't working or your doc is trying to improve some side effects, so adjustments to dosage are common.

chuck1957 6 Apr 2016

Peter as we used to say when you have medications like this you can't compair them by mg these are two different medications not related in any way. So it's like compairing an apple to an orange don't worry about this as far as milligrams goes the doctor well know what dose to start at and it is no where close to the mg of Gabapentin dose. These work for simular purposes but you can't compair them in anyway with the strength. Chuck1957

chuck1957 6 Apr 2016

Peter this is what I'm trying to say the doctor could use as much as 600mg a day But they have found that dose's above 300mg a day have proven to not be any more effective here is some info from the company I copied off this website. And rarely have I ever seen anyone take that high of the dose. chuck1957((((Neuropathic Pain Associated with Diabetic Peripheral Neuropathy

The maximum recommended dose of LYRICA is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Because LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function [see Dosage and Administration (2.6)].

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