... Does anyone know a way to test enbrel to see if it is still active. Does anyone know if it is still active after freezing? I called Amgen's enbrel support line and they were not helpful. I did a test and It is clear that if the styrofoam cooler stays below freezing for a few hours that the contents freeze. The medicine stopped working for the 3 months I had that shipment, then when I received a new shipment this Spring I was much better. My insurance company wants me to buy it mail order. Any thoughts or ideas?