our friends that have psoriais & or type 2 diabtes. My husband has severe psoriasis, & is a type 2 diabetic. This is quite interesting for these patients:
MUNICH – Psoriasis patients may be at an increased risk for type 2 diabetes, and the risk appears to be greatest among patients with severe psoriasis, researchers reported here.
Compared with the general population, patients with mild psoriasis had a 49% increased risk of developing diabetes, and individuals with severe psoriasis had a 2.13-fold increased relative risk when compared with the general population (P<0.0001), Ole Ahlehoff, MD, PhD, a post-doctoral fellow in cardiology at Copenhagen University Hospital Gentofte, reported at the European Society of Cardiology meeting.
"Psoriasis is a common inflammatory disease affecting approximately 125 million people worldwide," Ahlehoff said in a press briefing. He noted that previous studies have shown that patients with psoriasis are at a twofold risk of myocardial infarction, stroke, and death.
"Diabetes and psoriasis share an underlying inflammatory process and an abundance of risk factors and therefore it is not surprising that psoriasis has been proposed as a risk factor for new onset diabetes," he explained. "We therefore set out to test this hypothesis in a nationwide study of the entire Danish population since diagnosis of a risk factor for diabetes may allow for early detection and treatment."
Ahlehoff and colleagues reviewed records from the Danish National Health, which include office visits, use of medication, level of income, and other data points. "We looked at individuals in 1997 who were 10 years of age or older and followed them for 13 years until 2009. Patients who had psoriasis or diabetes at the starting point of the study were excluded."
The researchers started with a cohort of 4,614,807 and excluded 96,551 who had prevalent diabetes, creating a study cohort of 4,518,256 people.
The reference population (those who did not develop psoriasis) was 4,465,643.
Ahlehoff said the researchers identified 52,613 individuals who developed psoriasis after 1997; of those 45,829 were described as having mild psoriasis and 6,784 were diagnosed with severe psoriasis.
Among the findings:
The incidence rate of diabetes was 3.67 per 1,000 person-years (CI 3.65 to 3.69) in the reference group.
The rate was 6.93 per 1,000 person-years (CI 6.63 to 7.25) for those with mild psoriasis.
The rate was 9.65 per 1,000 person years (CI 6.63 to 7.25) for those diagnosed with severe psoriasis.
"The results reflect mainly type 2 diabetes," Ahlehoff said.
"Because of the huge database set for both overall population and psoriasis patients, all these figures are statistically significant," he told MedPage Today.
"The median follow-up of patients diagnosed with psoriasis was about 6 years, so that would indicate there is a short time span between diagnosis of psoriasis and subsequent diagnosis of new-onset diabetes," he said.
"Our results underline the importance of considering psoriatic patients as a high-risk population in terms of diabetes mellitus," Ahlehoff said.
"Screening for diabetes and cardiovascular risk factors in patients with psoriasis is warranted," he concluded.
He suggested that screening psoriasis patients once a year for diabetes would be reasonable, along with other classical cardiovascular risk factors such as cholesterol levels and high blood pressure
He said his findings support the hypothesis that an increased level of inflammation increases the risk of new onset diabetes.
"I wonder if these psoriasis cases were diagnosed though a skin biopsy," Gordon Tomaselli, MD, professor and director of Cardiology at the Johns Hopkins University School of Medicine and past president of the American Heart Association, told MedPage Today.
He said that people with diabetes often develop a thickening of the skin that might mimic psoriasis. "The association between psoriasis and inflammation is interesting. Could the link be inflammation? It could be."
Also intriguing, Tomaselli said, was the possibility that treating psoriasis might diminish the incidence of diabetes.
Hope this gives our psoriasis patients or diabetics some food for thought...