... the jaw?
Fosamax - What is the connection between this drug and cancer of the oesophagus and deterioration of
Added 4 Jan 2012:
I am a journalist and would like to be able to quote sources that confirm the cancer implications related to taking Fosimax. Can you give me some contacts/names please?
I don't know about cancer of the esophagus but it can cause esophageal cancers.
Postmarketing experience has reported esophagitis, esophageal erosions, esophageal ulcers, rarely esophageal stricture or perforation and oropharyngeal ulceration.
The combination of alendronate and naproxen has been reported as synergistic for development of gastric ulcers.
Gastrointestinal side effects have included abdominal pain, nausea, dyspepsia, constipation, diarrhea, and flatulence. Regurgitation, esophageal ulcer, vomiting, dysphagia, abdominal distention, and gastritis also have occurred. Rarely, taste perversion has been reported. The frequency of adverse effects increased with higher dosages.
Several cases of ulcerative esophagitis have been reported in patients receiving alendronate. Patients with preexisting esophageal disorders and those who take alendronate with little or no water and lie down immediately following ingestion may be at an increased risk.
AND yes, it can cause you to develop bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.
julispascal, I am going to reference you to a site. You may have to click on Clinical studeies highlighted in blue to get that info, but it's there. If taken as directed this is usually not a problem. I have gerd & take omprozole also. I took Fosamax, Actontel, daily weekly & monthly for osteoporosis & am now on Forteo which is finally rebuilding new bone. I stll agree that the ones that end up with a problem are not taking the med according to the directions & getting it into the stomach & staying upright for 30 minutes after. If any med (well most) disolves in the ephosphagus can cause eronion problems that can eventually lead to tother things such as cancer. Best of luck to you...
- Fosamax Information for Consumers
- Fosamax Information for Healthcare Professionals (includes dosage details)
- Side Effects of Fosamax (detailed)
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