I have a little more info to add to my question I posted a few minutes ago regarding pmdd. When I was taking Effexor XR (I believe it was 225 mg/day), I still experienced extreme pms. I did not take klonopin at that time. I have taken Wellbutrin SR, 300 mg/day, and klonopin (3 mg/day) for about three years, so it is not a new drug or dosage for me.