... My son has been on it for 4 years and he seems to be struggling progressively more and more each year. He was fine before he started the asthma medicines and his doctor seems to be dismissing my concerns
Restlessness, anxiety, nervousness, and irritability have all been associated with the use of Fluticasone/salmeterol.
See: https://www.drugs.com/sfx/fluticasone-salmeterol-side-effects.html (scroll down to nervous system)
Maybe you could take a printout of the above link to your doctor.
Your doctor could decide to change his asthma medications to see if his concentration improves.
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