I am on second day of fetzima, was on 225 of effexor. WEaning me off at same time. I have tried every antidepressant out there. I have MTHFR gene mutation which causes negative reactions to a lot of meds. I am hoping and praying this works. I am Bi-polar, major depressive, PTSD and anxiety. For three years now also have chronic fatigue syndrome which there is no cure and its downright depressing. Haven't been able to work in years yet keep getting denied disability . This has got to work, i am getting out of options. What about side effects i am so prone to them its like I am just waiting for something to happen.