I had to replace my patch on a red eye flight Thursday night and I was in my seat reaching up under my shirt and ended up putting the patch, instead of higher up on my chest, actually on the ample adipose tissue on one breast. The thing is, yesterday and today I feel a little withdrawal achy, surprising and not what I am use to. I am wondering if all the fat tissue of the breast is keeping it from distributing correctly. I will of course put my new one higher tonight but I would like to hear from any of you with knowledge or experience about how the patch works on different tissues of the body.