... week my chin (mostly) began to get small whiteheads. I have been post menopausal for about 3 years now, and like most woman, are taking osphena because of vaginal dryness/painful sex. I see information that rashes/hives can be a possible side effect, but what I am getting is just like before menopause..just before monthly period would start... teenage years... facial breakout. Definitely not rash/hives!