I am currently on Pristiq 50mg, Wellbutrin XL 300mg and Buspirone 30mg for depression and anxiety. Last fall my GP added in Seroquel to help me sleep. I was on it about a month or so, but found that I had weight gain associated with it, so it was discontinued. The tough part is, even though it was only 25mg once daily before bed, I think it helped with my moods. Has anyone had any experience with Seroquel as an adjunct to Depression and Anxiety meds? Would such a low dose of it before bed actually make a difference to mood? I really wish it hadn't caused me to gain weight.