I have been using Estring for 3 months, I had a total hysterectomy 6 years ago, at the age of 29. My bone density is extremely low and I had vaginal atrophy. The first two months were great with little side effects. However, in the last month my breasts have become extremely tender and I have gone up a cup size. I have been experiencing extreme abdominal pain, and joint stiffness. As well as, an 8 lb weight gain over the last three weeks. I have had no change to diet or exercise. The abdominal pain alone has made me decide to discontinue use, however; I am in nursing school and cannot afford to not feel well. So, I was wondering if anyone had experienced any negative symptoms after removing the ring. If so, I can wait until the weekend to do so. Thanks in advance for any help on this matter.