... to be awful. Now on Suboxone, does anyone know if Elavil will work again. Elavil is an older tricyclic antidepressant that seemed mild. S
Hi Scruffy2, I just started Suboxone 8mg and they make me so sleepy, I was wondering if they did you too? I also used to take Elavil for migraines and found sleeping was so easy on it. But I've never taken them together, so I'm not much help, but I wanted to friend you because I noticed we have a lot in common as I read your "topics" titles. Cathleen. I hope someone replies soon with a better answer !! :)
I am gonna try to explain this, but I am not a pharmacist so please don't take my word for it. Only a doctor or pharmacist can say for certain.
Elavil should still work even though you have been on suboxone. There is moderate drug interaction that you should be aware of:
Interactions between your selected drugs
amitriptyline ↔ buprenorphine
Applies to:Elavil (amitriptyline) and Suboxone (buprenorphine/naloxone)
MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.
MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
That being said, let me explain further. The suboxone contais buprenorphine, a pain killer, and naloxone, an atagonist of the opiate receptors in the brain. The naloxone binds to the opiate receptors blocking any opiate from attaching. Thus its use for precipitating opiate withdrawls and reversing opiate over dose.
Elavil (amitriptyline) acts on the brain in a different way. It prevents the neurotransmitters serotonin and dopamine from attaching to the receptors. There by keeping these two chemicals in the synaptic space between nerve cells longer.
Well, that being said , they act on the brain in different ways and therefore the suboxone isn't gonna keep the elavil from working. Make any sense? I might be all washed up on this but...
Hope this helps,
Laurie PS If I find more on this topic to share with you, I will.
Hi. I have the same problem with suboxone. I can only take it in the morning because if I take it in the afternoon or evening I can't sleep even if I take sleeping pills (benadryl works great for me). Also, if you have a good doctor and your having problems with high blood pressure or withdrawal clonodine will lower your blood pressure and make you tired. Elavil should still work and it even is good for headaches but suboxone is just so strong that it seems like it really over rides all medications. Can you take the suboxone only in the morning or will you get very sick if you don't take it in the afternoon/night? I wish I could be of more help and I'd love to keep in touch with you. Best wishes and hang in there :)
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