... 150mg that I may not be at my proper theraputic dose. My concern is, does it lose its effectiveness after a certain time> I don't want to keep upping my dose, I am supressed for the most part or calm if you want to call it that, but depressed and have anxiety, I read that at 150mg the noeprehine and the dopmanine will be more prominent and the dose should be more effective. I am hoping for the best I took two 75mg today.