Hello everyone. I'm suffering on a severe depression with anxiety for many years. I tried a lot of medications, but nothing really helped. But increasing effexor after taking it 4 months 150 mg to 250 mg changed my life for the following weeks. It was so incredible. My depression was completely vanished. After increasing it to 300 mg became manic and I stopped taking effexor. I felt still very good for 1 month without taking anything. Then the depression came back. I took effexor(250mg) again for 4 weeks and then I gave up. After trying another medication, that didn't help, I'm trying effexor now again already for 1 week, because my new doc told me that I should wait longer. How possible is it that effexor will work again for me? How long do I have to wait until I will work?