I have been taking Effexor for ten years starting from 150 after my menopause . I am 61 years old and have gained about 10 kilos more than before taking it. Life treated me very viciously (losing only brother in war, paralyzed mother, sick husband). Started Prozac 15 years ago then went to Effexor now trying to quit because of high bp and overweight and feeling not it is not working anymore.