Two years ago I was on Effexor 275 mg, I am PTSD, GAD, and bipolar. I was also on buspirone and gabapentin. I quickly became manic so they dropped the Effexor. I was put on Seroquel and have been struggling for the past year to get my anxiety which is getting worse under control. The doctor suggested Cymbalta but I am scared the same thing will happen over again. I have picked up my prescription for it but have not yet tried it.