The 37.5 ER made me feel very good, but it only last 5 days. After 5 days, it stopped working. I was in the hospital for anxiety, depression and insomia. They up the Effexor and it gave me th worst anxiety imaginable, non-stop. Took it 4 days. The nurse said it would take a few more days to work Without Ativan (I was a falling risk) I could not take the anxiety. Has anyone else had this happen?